What Is Dexilant? Dexilant (dexlansoprazole) is an oral medication that helps treat the symptoms of gastroesophageal reflux disease (GERD)—a condition that causes the acid in your stomach to flow backward, up into your esophagus, and cause
Dexilant (dexlansoprazole) is an oral medication that helps treat the symptoms of gastroesophageal reflux disease (GERD)—a condition that causes the acid in your stomach to flow backward, up into your esophagus, and cause heartburn. Dexilant also helps heal the lining of the esophagus (the tube that connects the throat to the stomach), which may become damaged due to stomach acid irritation.
Dexilant belongs to a group of medications called proton pump inhibitors, or PPIs. PPIs work by decreasing the amount of acid in the stomach.
While some PPIs are available over-the-counter (OTC), Dexilant requires a prescription, so you’ll need to visit your healthcare provider to see if this medication is an option for you.
Generic Name: Dexlansoprazole
Brand Name(s): Dexilant, Dexilant SoluTab, Kapidex
Administration Route(s): Oral
Drug Availability: Prescription
Therapeutic Classification: Proton pump inhibitor
Available Generically: Yes
Controlled Substance: N/A
Active Ingredient: Dexlansoprazole
Dosage Form(s): Delayed-release capsule
The Food and Drug Administration (FDA) approved Dexilant for people 12 years and older to:
Dexilant is taken once per day, with or without food. It is important to swallow the capsule whole and not chew the granules inside the capsule—doing so can affect how quickly Dexilant is released into your body.
Unlike other heartburn medications (e.g., Maalox, Tums, and others), Dexilant needs to be taken daily, as prescribed—not on an “as needed” basis—to work appropriately.
Store Dexilant at room temperature. Remember to keep Dexilant, and all your medications in a safe location, away from children and pets.
Healthcare providers may prescribe Dexilant for other conditions not approved by the FDA. Some common “off-label” uses of Dexilant include:
After starting Dexilant, you should begin to see improvements in your symptoms within five days. It is important to take Dexilant daily, as prescribed, and not just when you have symptoms.
This is not a complete list of side effects, and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your pharmacist or a healthcare provider. You may report side effects to the FDA at fda.gov/medwatch or 1-800-FDA-1088.
Dexilant is generally well-tolerated, but as with any drug, side effects can occur. Common side effects include:
Let your healthcare provider know if any of these side effects become bothersome or prevent you from taking your Dexilant as prescribed.
Dexilant may cause serious reactions in some people. Let your healthcare provider know right away if you experience a serious side effect. Call 911 if your symptoms feel life-threatening.
Dexilant may cause the following serious side effects:
Dexilant may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you have trouble swallowing pills, you can still take Dexilant. The capsules can be opened and sprinkled onto applesauce—just be sure not to chew the granules since they’re coated with a substance that releases Dexilant slowly into your body.
Follow these steps to take Dexilant with applesauce:
If you miss a dose of Dexilant, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and take your next dose regularly. Don’t double up or take extra Dexilant to make up for a missed dose.
Taking more than your prescribed dose of Dexilant can cause side effects, which can sometimes be serious. These side effects can include:
If you think you or someone else may have overdosed on Dexilant, call a healthcare provider or the Poison Control Center (800-222-1222).
If someone collapses, has a seizure, has trouble breathing, or can’t wake up after taking too much Dexilant, call 911 immediately.
It is important that your doctor check your or your child's progress at regular visits. This will allow your doctor to see if this medicine is working properly and to decide if you should continue to take it. Blood, urine, and other laboratory tests may be needed to check for unwanted effects.
Do not take this medicine if you are also using products that contain rilpivirine (Complera®, Edurant®).
This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Check with your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.
Check with your doctor right away if you have a fever, joint pain, skin rash, swelling of the body, feet, or ankles, or unusual weight gain after taking this medicine. These could be symptoms of a serious kidney problem called acute interstitial nephritis.
Taking this medicine for a long time may make it harder for your body to absorb vitamin B12. Tell your doctor if you have concerns about vitamin B12 deficiency.
Check with your doctor right away if you have watery stool that does not go away, stomach pain, and fever while taking this medicine.
Dexlansoprazole may increase your risk of having fractures of the hip, wrist, and spine. This is more likely if you are 50 years of age and older, if you receive high doses of this medicine, or use it for one year or more.
Cutaneous or systemic lupus erythematosus may occur or get worse in patients receiving a PPI. Call your doctor right away if you have joint pain or a skin rash on your cheeks or arms that gets worse when exposed to the sun.
This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are taking this medicine for more than 1 year, or if you are taking this medicine together with digoxin (Lanoxin®) or certain diuretics (water pills). Check with your doctor right away if you have convulsions (seizures), fast, racing, or uneven heartbeat, muscle spasms (tetany), tremors, or unusual tiredness or weakness.
This medicine may increase your risk for fundic gland polyps (abnormal tissue growth in the upper part of your stomach). This is more likely if you are receiving this medicine for more than 1 year. Talk to your doctor if you have concerns.
Do not stop taking this medicine without first checking with your doctor, or unless told to do so by your doctor.
Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription (eg, atazanavir, Reyataz®) or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.
You should not take Dexilant with any drugs containing rilpivirine—a medication used to treat HIV. Dexilant can decrease rilpivirine levels and reduce how well it works against HIV. Products that contain rilpivirine include:
Let your healthcare provider know about all your allergies. You should not take Dexilant if you are allergic to the active ingredient (dexlansoprazole) or any other component of Dexilant.
Dexilant can interact with many medications. Always keep an updated list of all the medicines you take, including herbal and nonprescription products. Share this information with your healthcare provider and pharmacist any time there are changes.
Let your healthcare provider know if you take any of the following medications. They may recommend avoiding Dexilant or adjusting the dose of your other medication:
This is not a complete list of all the drugs that can interact with Dexilant. Always review the medications you take with your healthcare provider and pharmacist before starting anything new.
Several PPI medications are available to treat heartburn and other stomach acid-related conditions. PPIs are typically considered equally effective at reducing symptoms and healing the esophagus. Side effects are also similar, although you may find you tolerate one PPI better than another.
Choosing a PPI often depends on:
In addition to Dexilant, available PPIs include:
This is a list of similar drugs—not drugs you should take with Dexilant. In fact, you should not take these drugs together. Ask your pharmacist or healthcare provider if you have any questions about your medications.
Dexilant is FDA-approved to treat heartburn due to GERD (gastroesophageal reflux disease) and help heal the esophagus's lining from stomach acid-related damage. Healthcare providers also prescribe Dexilant for several other conditions, including symptoms of upset stomach, peptic ulcer disease, and H.pylori infections (along with antibiotics).
Dexilant works by reducing the amount of acid in your stomach.
Dexilant can affect how many drugs work. Be sure to let your healthcare provider and pharmacist know if you take any medications that contain rilpivirine (a drug used to treat HIV) or methotrexate since serious reactions can occur. Many other drugs can interact with Dexilant. Let your healthcare provider and pharmacist know about all the medications you take—even over-the-counter, nonprescription products— they can ensure your regimen is safe.
You should begin to see an improvement in your symptoms within five days after starting Dexilant. For Dexilant to work, it needs to be taken daily, not just when you have symptoms.
The most common side effects of Dexilant include:
If you’ve been struggling to get your heartburn under control, talk to your healthcare provider about Dexilant. Dexilant is a safe and effective option that can help treat the uncomfortable symptoms of acid reflux and heal the esophagus lining. Be sure to only take Dexilant for the amount of time prescribed by your healthcare provider. The longer you take Dexilant, the greater your risk of side effects. If you require long-term treatment with Dexilant, you and your healthcare provider will work together to develop a monitoring plan to keep you healthy and feeling your best.
Verywell Health's drug information is meant for educational purposes only and is not intended as a replacement for medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.