Dysfunction surrounding dopamine and ADHD could be linked. Learn more about this neurotransmitter that helps control emotions and movement and ADHD. Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition that causes hyperactivity and difficulty maintaining attention. It typically begins during childhood and often continues into adulthood. According to the Food and Drug
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition that causes hyperactivity and difficulty maintaining attention. It typically begins during childhood and often continues into adulthood. According to the Food and Drug Administration (FDA), 13.2% of boys and 5.6% of girls are diagnosed with ADHD.
The exact cause of ADHD is not known, but it is associated with changes in neurotransmitter activity in certain areas of the brain. Neurotransmitters are chemicals that coordinate the action of the nervous system.
The neurotransmitters most closely associated with ADHD are dopamine, serotonin, norepinephrine, and epinephrine. These neurotransmitters have similar chemical structures, and they are formed by interconnected biochemical processes.
The actions of neurotransmitters involved in ADHD are:
Research studies examining the metabolic activity of the brain have found that the action of these neurotransmitters is disrupted in people who have ADHD. The changes may be associated with differences in a person's genetic makeup. The neurotransmitter change that is most significant in ADHD is a decrease in dopamine activity.
One complicated aspect of the neurotransmitter disruption in ADHD is that it might not be consistent throughout life, and there isn’t a clear link between the amount of any of the neurotransmitters and the severity of ADHD symptoms.
Dopamine transporters are proteins that regulate the action of dopamine by prolonging or terminating the action of the neurotransmitter.
Some studies using functional neuroimaging techniques such as positron-emission tomography (PET) scans have found that ADHD is associated with abnormalities of dopamine transporters in certain areas of the brain. The abnormalities in dopamine transporters vary with age and are impacted by medication.
Dopamine dysfunction in ADHD is associated with a change in the dopamine transporter gene. A genetic change described as the VNTR polymorphism (DAT1 VNTR; rs28363170) is one of the most consistent genetic markers of ADHD.
Additionally, transporters for serotonin, norepinephrine, and epinephrine may have irregularities in people with ADHD as well.
For example, one research study reported an increase in dopamine transporter activity in the striatum (located in the forebrain), decreased dopamine transporter activity in the cingulate (another brain area), and decreased serotonin transporter activity in the striatum and midbrain. Study authors suggest that the inconsistencies could be related to compensatory mechanisms (the body taking actions due to the increased dopamine transporter activity).
Changes in dopamine levels and dopamine activity are involved in several different medical conditions.
For instance, dopamine levels are sometimes described as being too high or too low, but research suggests that the disorders are caused by more complex changes than high or low levels of dopamine.
In addition, the effects of these different conditions can also be related to alterations in dopamine activity in specific regions of the brain.
Many of the conditions associated with dopamine alterations are also associated with changes in other neurotransmitters as well, which adds to the complexity of the disorders and their treatments.
Conditions associated with dopamine changes in the brain include:
The treatments used for managing ADHD include behavioral therapy, counseling, and medications. Many children and adults benefit from using strategies to stay organized and on task. Getting regular physical exercise and sleep can be beneficial as well.
Prescription stimulants are often used to treat ADHD. These medications increase the levels of dopamine in the brain. However, they can cause side effects, such as insomnia and weight loss.
Stimulants used to treat ADHD include:
Several medications approved for treatment of ADHD are not considered stimulants.
Non-stimulant ADHD medications include:
Attention deficit hyperactivity disorder (ADHD) is a condition that causes problems with attention and behavior. Some of the treatments help manage this condition have an effect on dopamine or other neurotransmitter action in the brain, and the condition has been linked to changes in dopamine levels in some regions of the brain.
There is also evidence that alterations in serotonin, epinephrine, and norepinephrine may have an effect as well. Research about the biochemical changes and structural brain changes in ADHD is ongoing.
If you or your child has ADHD, it’s important to know that there are effective treatments. A multidisciplinary approach that includes lifestyle changes, therapy, and medication is usually recommended.
Changes in dopamine activity are involved in ADHD, but the link is not straightforward, and it might not be consistent at different ages or at different stages of the disorder.
Diminished dopamine activity is part of ADHD, but it is not the only abnormality that has been identified with the condition. Other conditions that are associated with diminished dopamine activity, such as addiction and Parkinson’s disease, have symptoms that are very different from the symptoms of ADHD.
The behaviors associated with ADHD may trigger the effects of dopamine, and this is believed to be related to a deficit in dopamine activity.
Sometimes people who have the condition can become addicted to actions or medications that increase the effects of dopamine, but this is not always the case.
A dopamine crash is thought to be extreme fluctuations in dopamine that cause unpleasant physical or emotional effects.
It’s important to eat enough protein-containing foods so your body can make dopamine. The amino acid tyrosine is a building block of dopamine. You can get enough tyrosine from most foods that contain protein.
If you have a disease that is associated with a deficiency of dopamine function, eating more protein is unlikely to help because the problem is rooted in the process of dopamine production or with the action of dopamine receptors. Eating more food that contains tyrosine or taking supplements won’t help.