What Is Qulipta? Qulipta (atogepant) is a medication option that's used to prevent migraines in adults. It's in the calcitonin gene-related peptide (CGRP) receptor antagonist drug class.Qulipta blocks the CGRP receptor (binding site) to prevent
Qulipta (atogepant) is a medication option that's used to prevent migraines in adults. It's in the calcitonin gene-related peptide (CGRP) receptor antagonist drug class.
Qulipta blocks the CGRP receptor (binding site) to prevent the attachment of the CGRP protein. The CGRP protein is thought to play a role in migraines by causing inflammation (swelling) of the meninges (protective layers that cover the brain). Migraines are less likely to occur if the CGRP protein can't bind to its binding site.
Qulipta is available as a prescription tablet. The Food and Drug Administration (FDA) hasn't assigned any black box warnings to this medication.
Generic Name: Atogepant
Brand Name(s): Qulipta
Drug Availability: Prescription
Therapeutic Classification: Calcitonin gene-related peptide (CGRP) receptor antagonist
Available Generically: No
Controlled Substance: N/A
Administration Route: Oral (by mouth)
Active Ingredient: Atogepant
Dosage Form(s): Tablet
Qulipta is a medication used to prevent migraines in adults.
Migraines affect more than 29 million people in the United States)—most of whom (75%) are people assigned female at birth. Migraines are painful headaches that may last for hours or days and tend to occur on one side of your head. Migraine symptoms may also include nausea, vomiting, and light or sound sensitivity.
Take Qulipta once daily by mouth, with or without food.
After receiving Qulipta from the pharmacy, store your medication at room temperature, which is between 68 degrees and 77 degrees Fahrenheit. Temporarily storing in temperatures between 59 degrees and 86 degrees is permitted for short periods.
If you're planning to travel with Qulipta, become familiar with the regulations of your final destination. In general, however, make a copy of your Qulipta prescription. It's also a good idea to keep your medication in its original container from the pharmacy, with your name on the label.
Some people have noticed fewer migraines between one and four weeks of starting Qulipta.
This is not a complete list of side effects and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your pharmacist or a healthcare provider. You may report side effects to the FDA at fda.gov/medwatch or 800-FDA-1088.
Common side effects with Qulipta include:
The FDA doesn't include details about Qulipta's severe side effects on its label. If you think that you're experiencing life-threatening side effects, however, get medical help right away.
Based on a 52-week clinical study, there were no safety concerns with Qulipta. More research, however, is needed.
Qulipta may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
The following modifications (changes) should be kept in mind when using Qulipta:
Pregnancy: In animal studies, high doses of Qulipta were linked to negative effects on the unborn fetus. Not enough information is available about the safety and effectiveness of Qulipta in pregnant people. Ask your healthcare provider to weigh the benefits and risks of taking Qulipta during your pregnancy.
Breastfeeding: In animal studies, Qulipta was present in rats' breastmilk. The safety of Qulipta in human breastmilk is not known. Discuss with your healthcare provider the benefits and risks of taking Qulipta while nursing and different ways of feeding your baby while taking Qulipta.
People with kidney problems: If you have end-stage renal (kidney) disease (ESRD), your healthcare provider will usually recommend a maximum daily Qulipta dose of 10 milligrams (mg). If you're getting dialysis (a process that removes excess water and toxins from the blood), then take Qulipta after your dialysis appointment.
People with liver problems: If you have severe liver impairment, your healthcare provider will typically recommend avoiding Qulipta.
People taking other medications: Some medications interact with Qulipta. If necessary, your healthcare provider can change your daily Qulipta dose to prevent side effects or problems with how well it's working. If you have any concerns or questions about potential medication interactions with Qulipta, talk with your pharmacist or healthcare provider.
If you accidentally forgot your Qulipta dose, take it as soon as you remember. If it's already close to your next scheduled dose, however, skip the missed dose and take the following dose at your next scheduled dosing time. Don't try to double up to make up for the missed dose.
Try to find ways to help yourself remember to routinely take your medication. If you miss too many doses, Qulipta might be less effective at preventing your migraines.
The FDA doesn't include details about overdose-related effects for Qulipta on its label. If you think that you're experiencing an overdose or life-threatening symptoms, however, seek immediate medical attention.
If you think you or someone else may have overdosed on Qulipta, call a healthcare provider or the Poison Control Center (800-222-1222).
If someone collapses or isn't breathing after taking Qulipta, call 911 immediately.
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it.
If your symptoms do not improve within a few days or if they become worse, check with your doctor.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. Tell your doctor if you drink grapefruit juice.
The FDA doesn't include details about contraindication-related details for Qulipta on its label. Before taking Qulipta, however, talk with your healthcare provider if any of the following applies to you:
Use caution when taking Qulipta with the following medications:
For more detailed information about medication interactions with Qulipta, talk with your pharmacist or healthcare provider.
Also, tell your provider of all the medicines, supplements, and herbal or plant-based medicines you take. In addition to those mentioned above, taking certain medications, including the following, may require your provider to adjust your Qulipta dose:
There are a number of CGRP-inhibiting medications used for migraines. Some CGRP inhibitors are biologics (made from naturally occurring sources—like proteins and sugars), while others are non-biologics (chemical-based). Qulipta is a non-biologic CGRP inhibitor.
The following medications are the most similar to Qulipta:
These medications—along with Qulipta—are also known as "gepants." There are no studies that compare different gepants yet. The following, however, include some interesting information about the different gepants:
Qulipta is available with a prescription from your healthcare provider. Your local retail pharmacy should carry Qulipta. If necessary, your pharmacy staff may need to order the medication for you.
Qulipta isn't available as a generic yet. So, the medication can be expensive without insurance coverage. If cost is a concern, Qulipta's manufacturer does offer a savings program for people with commercial insurance. For eligibility questions, visit manufacturer AbbVie's website or call 855-785-4782.
People taking Qulipta usually experience 50% fewer migraines than they typically get.
Qulipta is used to prevent migraines. Your healthcare provider may also prescribe a medication to treat (relieve) migraine attacks. If you have any questions about your migraine-related medications, talk with your healthcare provider.
If you're taking Qulipta, chances are migraines have been affecting your quality of life. You've probably also tried a number of different medications. While living with migraines does have its challenges, there are ways to help improve your quality of life. The following are general tips:
Verywell Health's drug information is meant for educational purposes only and is not intended as a replacement for medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.